منابع مشابه
Preparing to unwind
A combination of protein crystallography and biochemistry has revealed how a ring-shaped helicase might trap a single DNA strand as the double helix melts, and before it is unwound.
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Political developments in Britain since 2001 provide reason to believe that the nature of tactical voting at the 2005 general election may have been different in character from that in other recent elections. This paper examines the changes in party preference structure and finds no sign of greater distance between Labour and the Liberal Democrats. Instead the most notable change is a collapse ...
متن کاملPutting Two Heads Together to Unwind DNA
The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
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Several rare human genetic diseases are characterized at the cellular level by a high incidence of chromosomal rearrangements. Some of these disorders — in particular, xeroderma pigmentosum — are associated with abnormalities in the repair of DNA damage, whereas others — notably Fanconi’s anaemia and Bloom’s syndrome — are not. Rapid progress has been made in recent years in the characterisatio...
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http://ccn.aacnjournals.org Sandra Lins is the Blue Cross/Blue Shield Michigan Cardiovascular Consortium project coordinator at Oakwood Hospital and Medical Center in Dearborn, Mich. She coordinates all data collection and quality improvement efforts related to percutaneous coronary interventions. Denise Guffey is the former manager of the cardiac catheterization laboratory at Oakwood Hospital ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2011
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3067